Fast HPLC- Where Are We Four Years Later?
 Monday, March 3, 2008
1:30 p.m., Room 236

Organizer:

Michael McGinley and Jason Anspach, Phenomenex

Speakers:

1:35     Smaller Particles, Higher Pressures, and Faster Separations: The Current Status of Pharmaceutical Method Development Five Years Later  TODD D MALONEY, Eli Lilly and Company, John D Stafford, Bryan C Castle

2:05     Overcoming the Limitations of Sub 2 µm Materials in High Speed HPLC Methods  JASON A ANSPACH, Phenomenex, Liming Peng, Gareth Friedlander, Graham Osborn, Peter C Rahn

2:35     Fast LC Using Small Particles with Optimized Conventional HPLC and U-HPLC Technology in Early Pharmaceutical Development   CHRISTOPHER JAMES FOTI, Pfizer, Justin D Ringling, Chris A Wood, Ricardo E Borjas

3:05     Recess

3:20     Performance Characterizations and Comparisons of HPLC Column Options for Ultra High-Speed and High-Resolution HPLC Separations  MAUREEN JOSEPH, Agilent Technologies, William Barber, William Long, Brian Bidlingmeyer

3:50     Fast Analysis Using Microflow LC at Elevated Temperatures and Smaller Particles  JASON ANDREW STARKEY, Eksigent Technologies, Hung-Yuan Cheng, Phillip H DeLand, Remco Van Soest

4:20     Achieving High Speed HPLC Performance at Moderate Pressures   HILLEL BRANDES, Supelco, William Campbell, Richard A Henry, Wayne K Way, Russel Gant, Paul Ross, David S Bell

Overview:

HPLC Instrument and column manufacturers have generated significant excitement in the analytical chemistry world over the last four years with the introduction of ultra high-pressure LC systems using sub-2µm materials. Parallel innovations in other silica media technologies such as superficially porous medias and monoliths have also led to improvements in high-speed chromatography. With such a pace of discovery, it has become difficult for some to differentiate between "marketing message" and practical innovations in deciding what technologies to implement across a research organization. Some organizations are rapidly adopting these new technologies with demonstrated improvements in efficency, while others have rejected some new products due to technical difficulties.

This workshop assembles different points of view regarding implementation of fast HPLC technologies. Several leaders in both the pharmaceutical industry as well as HPLC manufacturers have been gathered to give their opinions regarding their experiences with fast HPLC. The history of technology development and adaptation by specific organizations will be discussed; in addition the strengths and weaknesses of specific solutions with be reviewed by both vendors and users. Some commentary should give attendees a sense of where the industry has come over the last four years as well as a hint of where future innovations may be seen.