Comprehensive Multidimensional Separations
 Wednesday, March 5, 2008
1:30 p.m., Room 245 

Organizer:

Tadeusz Gorecki, University of Waterloo

Speakers:

1:30     Discovery-Based Metabolomics Using GC x GC-TOFMS and Chemometric Data Analysis  ROBERT E SYNOVEC, University of Washington

1:50     Arson Accelerant Identification by Chemometric Analysis of GC x GC-TOFMS Chromatograms  GREGORY J HALL, U.S. Coast Guard Academy, Glenn S Frysinger, Kristen L Serumgard, Richard B Gaines

2:10      Implications of the Modulation Ratio for Quantitation in Comprehensive Multidimensional Separations:  A Theoretical Approach  JAMES J HARYNUK, University of Alberta, Andrew Kwong, Philip J Marriott

2:30      Stop-Flow GC×GC with Pneumatic Switching  TADEUSZ GORECKI, University of Waterloo, Nathan Oldridge, Ognjen Panic

2:50      Recess

3:05      Chronic Disease Biomonitoring through GCxGC:  Recent Advances and Perspectives  JEAN-MARIE D DIMANDJA, Spelman College

3:25      Comparison of One-Dimensional and Comprehensive Two-Dimensional Chromatographic Techniques  PAT J SANDRA, Ghent University, Isabelle P Francois, Frank David

3:45      Simplification of Multidimensional HPLC and Column Switching   HAIBIN WAN, PromoChrom Technologies

Overview:

Conventional chromatographic techniques are very powerful, yet some samples are simply too complex to be effectively analyzed by them. Analyses of very complex mixtures are performed in many areas, including petroleum industry,where proper characterization of petroleum products is of critical importance; the forensic sector, striving to improve pattern recognition within complex matrices; as well as food and fragrance, environmental and health sectors, where trace analysis of target analytes in complex matrices is required together with the ability to characterize unknown samples. In all these examples, it is impossible to accomplish complete separation of all sample components by relying on a single separation mechanism. This has been the thrust behind the development of multi-dimensional techniques. Comprehensive multi-dimensional chromatographic techniques developed recently represent probably the greatest step forward in separation science
in many years. The session will be devoted entirely to multidimensional separations, with presentations by leading experts in the field. Talks will cover both comprehensive two-dimensional gas chromatography (GCxGC), and comprehensive two-dimensional liquid chromatography (LCxLC).